Regulation of nuclear Prointerleukin-16 and p27Kip1 in primary human T lymphocytes
KC Wilson, DJ Cattel, Z Wan, S Rahangdale, F Ren… - Cellular …, 2005 - Elsevier
Prointerleukin-16 (Pro-IL-16) is an abundant, PDZ domain-containing protein expressed in
the nucleus and cytoplasm of resting human T lymphocytes. We have previously shown that
ectopic expression of Pro-IL-16 in Pro-IL-16-negative human Jurkat cells represses
transcription of the F-box protein, Skp2, resulting in accumulation of the cyclin-dependent
kinase inhibitor, p27Kip1, and G0/G1 cell cycle arrest. The current studies demonstrate the
kinetics of Pro-IL-16 and p27Kip1 expression in activated normal human T lymphocytes. We …
the nucleus and cytoplasm of resting human T lymphocytes. We have previously shown that
ectopic expression of Pro-IL-16 in Pro-IL-16-negative human Jurkat cells represses
transcription of the F-box protein, Skp2, resulting in accumulation of the cyclin-dependent
kinase inhibitor, p27Kip1, and G0/G1 cell cycle arrest. The current studies demonstrate the
kinetics of Pro-IL-16 and p27Kip1 expression in activated normal human T lymphocytes. We …