[HTML][HTML] Connexin-36 contributes to control function of insulin-producing cells
S Le Gurun, D Martin, A Formenton, P Maechler… - Journal of Biological …, 2003 - ASBMB
Connexin-36 (Cx36) is a gap junction protein expressed by the insulin-producing β-cells.
We investigated the contribution of this protein in normal β-cell function by using a viral gene
transfer approach to alter Cx36 content in the insulin-producing line of INS-1E cells and rat
pancreatic islets. Transcripts for Cx43, Cx45, and Cx36 were detected by reverse
transcriptase-PCR in freshly isolated pancreatic islets, whereas only a transcript for Cx36
was detected in INS-1E cells. After infection with a sense viral vector, which induced de novo …
We investigated the contribution of this protein in normal β-cell function by using a viral gene
transfer approach to alter Cx36 content in the insulin-producing line of INS-1E cells and rat
pancreatic islets. Transcripts for Cx43, Cx45, and Cx36 were detected by reverse
transcriptase-PCR in freshly isolated pancreatic islets, whereas only a transcript for Cx36
was detected in INS-1E cells. After infection with a sense viral vector, which induced de novo …