The protein deacetylase, sirtuin 1 (SIRT1), is a proposed master regulator of exercise-
induced mitochondrial biogenesis in skeletal muscle, primarily via its ability to deacetylate
and activate peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). To
investigate regulation of mitochondrial biogenesis by SIRT1 in vivo, we generated mice
lacking SIRT1 deacetylase activity in skeletal muscle (mKO). We hypothesized that
deacetylation of PGC-1α and mitochondrial biogenesis in sedentary mice and after …