Early removal of alternatively activated macrophages leads to Taenia crassiceps cysticercosis clearance in vivo

JL Reyes, CA Terrazas, J Alonso-Trujillo… - International journal for …, 2010 - Elsevier
To determine the role of alternatively activated macrophages in modulating the outcome of
experimental cysticercosis caused by Taenia crassiceps, we investigated the effect of
removal of alternatively activated macrophage by injecting clodronate-loaded liposomes into
susceptible BALB/c mice. Following T. crassiceps infection, mice receiving PBS-loaded
liposomes developed a dominant Th2-type response associated with the presence of
alternatively activated macrophages together with antigen-specific hyporesponsiveness and …