B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD. c3c4 model of autoimmune cholangitis
Y Moritoki, M Tsuda, K Tsuneyama, W Zhang… - Cellular …, 2011 - Elsevier
There are now several murine models of autoimmune cholangitis that have features both
similar and distinct from human PBC. One such model, the NOD. c3c4 mouse, manifests
portal cell infiltrates, anti-mitochondrial antibodies but also biliary cysts. The biliary cysts are
not a component of PBC and not found in the other murine models. To address the
immunopathology in these mice, we generated genetically B cell deficient Igμ−/− NOD. c3c4
mice and compared the immunopathology of these animals to control B cell sufficient NOD …
similar and distinct from human PBC. One such model, the NOD. c3c4 mouse, manifests
portal cell infiltrates, anti-mitochondrial antibodies but also biliary cysts. The biliary cysts are
not a component of PBC and not found in the other murine models. To address the
immunopathology in these mice, we generated genetically B cell deficient Igμ−/− NOD. c3c4
mice and compared the immunopathology of these animals to control B cell sufficient NOD …