[HTML][HTML] Brain-specific proteins decline in the cerebrospinal fluid of humans with Huntington disease
Q Fang, A Strand, W Law, VM Faca… - Molecular & Cellular …, 2009 - ASBMB
We integrated five sets of proteomics data profiling the constituents of cerebrospinal fluid
(CSF) derived from Huntington disease (HD)-affected and-unaffected individuals with
genomics data profiling various human and mouse tissues, including the human HD brain.
Based on an integrated analysis, we found that brain-specific proteins are 1.8 times more
likely to be observed in CSF than in plasma, that brain-specific proteins tend to decrease in
HD CSF compared with unaffected CSF, and that 81% of brain-specific proteins have …
(CSF) derived from Huntington disease (HD)-affected and-unaffected individuals with
genomics data profiling various human and mouse tissues, including the human HD brain.
Based on an integrated analysis, we found that brain-specific proteins are 1.8 times more
likely to be observed in CSF than in plasma, that brain-specific proteins tend to decrease in
HD CSF compared with unaffected CSF, and that 81% of brain-specific proteins have …