Infection in the pathogenesis and course of chronic obstructive pulmonary disease

S Sethi, TF Murphy - New England Journal of Medicine, 2008 - Mass Medical Soc
New England Journal of Medicine, 2008Mass Medical Soc
New molecular, cellular, and immunologic techniques used to study host–pathogen
interactions have led to a reexamination of the role of infection in chronic obstructive
pulmonary disease (COPD). There is now considerable evidence that infection plays a
major role in the pathogenesis and clinical course of COPD. A vicious circle of infection and
inflammation is thought to lead to exacerbations of the disease.
New molecular, cellular, and immunologic techniques used to study host–pathogen interactions have led to a reexamination of the role of infection in chronic obstructive pulmonary disease (COPD). There is now considerable evidence that infection plays a major role in the pathogenesis and clinical course of COPD. A vicious circle of infection and inflammation is thought to lead to exacerbations of the disease.
The New England Journal Of Medicine