Active collagen synthesis by pulmonary arteries in pulmonary hypertension complicated by congenital diaphragmatic hernia
T Yamataka, P Puri - Journal of pediatric surgery, 1997 - Elsevier
The high mortality rate for patients with congenital diaphragmatic hernia (CDH) has been
attributed to pulmonary hypoplasia and persistent pulmonary hypertension (PPH). The
factors that cause vasoconstriction and vascular remodeling in PPH are not fully understood.
Immunohistochemistry was performed on lung tissue obtained from postmortem CDH
patients with pulmonary hypoplasia and PPH (n= 21) using the following antibodies: alpha
smooth muscle-actin (ASMA), transforming growth factor-beta (TGF-β), isoform specific (TGF …
attributed to pulmonary hypoplasia and persistent pulmonary hypertension (PPH). The
factors that cause vasoconstriction and vascular remodeling in PPH are not fully understood.
Immunohistochemistry was performed on lung tissue obtained from postmortem CDH
patients with pulmonary hypoplasia and PPH (n= 21) using the following antibodies: alpha
smooth muscle-actin (ASMA), transforming growth factor-beta (TGF-β), isoform specific (TGF …