Kidney injury molecule-1
JV Bonventre, L Yang - Current opinion in critical care, 2010 - journals.lww.com
JV Bonventre, L Yang
Current opinion in critical care, 2010•journals.lww.comKIM-1 mediates epithelial phagocytosis in the injured kidney converting the proximal
epithelial cell into a phagocyte, with potentially important pathophysiological implications for
modulation of the immune response and repair process after injury. KIM-1 serves as a highly
sensitive and specific urinary biomarker for kidney injury and may also be a therapeutic
target for various kidney diseases.
epithelial cell into a phagocyte, with potentially important pathophysiological implications for
modulation of the immune response and repair process after injury. KIM-1 serves as a highly
sensitive and specific urinary biomarker for kidney injury and may also be a therapeutic
target for various kidney diseases.
Summary
KIM-1 mediates epithelial phagocytosis in the injured kidney converting the proximal epithelial cell into a phagocyte, with potentially important pathophysiological implications for modulation of the immune response and repair process after injury. KIM-1 serves as a highly sensitive and specific urinary biomarker for kidney injury and may also be a therapeutic target for various kidney diseases.
Lippincott Williams & Wilkins