[HTML][HTML] SIGMA2: A system for the integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and transcriptomes
BMC bioinformatics, 2008•Springer
Background High throughput microarray technologies have afforded the investigation of
genomes, epigenomes, and transcriptomes at unprecedented resolution. However, software
packages to handle, analyze, and visualize data from these multiple'omics disciplines have
not been adequately developed. Results Here, we present SIGMA 2, a system for the
integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and
transcriptomes. Multi-dimensional datasets can be simultaneously visualized and analyzed …
genomes, epigenomes, and transcriptomes at unprecedented resolution. However, software
packages to handle, analyze, and visualize data from these multiple'omics disciplines have
not been adequately developed. Results Here, we present SIGMA 2, a system for the
integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and
transcriptomes. Multi-dimensional datasets can be simultaneously visualized and analyzed …
Background
High throughput microarray technologies have afforded the investigation of genomes, epigenomes, and transcriptomes at unprecedented resolution. However, software packages to handle, analyze, and visualize data from these multiple 'omics disciplines have not been adequately developed.
Results
Here, we present SIGMA2, a system for the integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and transcriptomes. Multi-dimensional datasets can be simultaneously visualized and analyzed with respect to each dimension, allowing combinatorial integration of the different assays belonging to the different 'omics.
Conclusion
The identification of genes altered at multiple levels such as copy number, loss of heterozygosity (LOH), DNA methylation and the detection of consequential changes in gene expression can be concertedly performed, establishing SIGMA2 as a novel tool to facilitate the high throughput systems biology analysis of cancer.
Springer