Transcriptional regulation of podocyte gene expression in primary glomerular disease is
poorly understood. In this study, we demonstrate a prominent role of members of the ZHX
(zinc fingers and homeoboxes) family of proteins in regulating podocyte gene expression
during the development of nephrotic syndrome. While studying mechanisms of glomerular
disease, rat ZHX3 was cloned from a down-regulated gene fragment; its cellular localization,
DNA binding, and transcriptional repressor properties were characterized; and its ability to …