[HTML][HTML] Novel propeptide function in 20 S proteasome assembly influences β subunit composition
DJ Kingsbury, TA Griffin, RA Colbert - Journal of Biological Chemistry, 2000 - ASBMB
The assembly of eukaryotic 20 S proteasomes involves the formation of half-proteasomes
where precursor β-type subunits gather in position on an α-subunit ring, followed by the
association of two half-proteasomes and β-subunit processing. In vertebrates three
additional β-subunits (β1i/LMP2, β2i/MECL1, and β5i/LMP7) can be synthesized and
substituted for constitutive homologues (β1/delta, β2/Z, and β5/X) to yield
immunoproteasomes, which are important for generating certain antigenic peptides. We …
where precursor β-type subunits gather in position on an α-subunit ring, followed by the
association of two half-proteasomes and β-subunit processing. In vertebrates three
additional β-subunits (β1i/LMP2, β2i/MECL1, and β5i/LMP7) can be synthesized and
substituted for constitutive homologues (β1/delta, β2/Z, and β5/X) to yield
immunoproteasomes, which are important for generating certain antigenic peptides. We …