[HTML][HTML] Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice
R Koldamova, M Staufenbiel, I Lefterov - Journal of Biological Chemistry, 2005 - ASBMB
ABCA1 (ATP-binding cassette transporter A1) is a major regulator of cholesterol efflux and
high density lipoprotein (HDL) metabolism. Mutations in human ABCA1 cause severe HDL
deficiencies characterized by the virtual absence of apoA-I and HDL and prevalent
atherosclerosis. Recently, it has been reported that the lack of ABCA1 causes a significant
reduction of apoE protein level in the brain of ABCA1 knock-out (ABCA1-/-) mice. ApoE
isoforms strongly affect Alzheimer disease (AD) pathology and risk. To determine further the …
high density lipoprotein (HDL) metabolism. Mutations in human ABCA1 cause severe HDL
deficiencies characterized by the virtual absence of apoA-I and HDL and prevalent
atherosclerosis. Recently, it has been reported that the lack of ABCA1 causes a significant
reduction of apoE protein level in the brain of ABCA1 knock-out (ABCA1-/-) mice. ApoE
isoforms strongly affect Alzheimer disease (AD) pathology and risk. To determine further the …