Down-regulation of vasoactive intestinal polypeptide receptor expression in atopic dermatitis
DA Groneberg, P Welker, TC Fischer, QT Dinh… - Journal of allergy and …, 2003 - Elsevier
Background: Receptors for vasoactive intestinal polypeptide (VIP) have recently been
suggested to play a key role in immunomodulation with genetically modified mice. However,
it is not known whether changes in receptor gene regulation are involved in the
pathogenesis of human immune disorders. Objective: We studied the expression of VPAC2
in acute lesions of the human immune disease atopic dermatitis. Methods: By using
nonradioactive in situ hybridization, quantitative immunohistochemistry, RT-PCR, and gene …
suggested to play a key role in immunomodulation with genetically modified mice. However,
it is not known whether changes in receptor gene regulation are involved in the
pathogenesis of human immune disorders. Objective: We studied the expression of VPAC2
in acute lesions of the human immune disease atopic dermatitis. Methods: By using
nonradioactive in situ hybridization, quantitative immunohistochemistry, RT-PCR, and gene …