[PDF][PDF] Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction
JR Muppidi, J Tschopp, RM Siegel - Immunity, 2004 - cell.com
JR Muppidi, J Tschopp, RM Siegel
Immunity, 2004•cell.comSignaling by receptors in the TNF receptor (TNFR) superfamily mediate biological outcomes
ranging from inflammation to apoptosis and other forms of programmed cell death. How
receptor signaling mediates these divergent responses is just beginning to be understood.
Here, we discuss how receptor submembrane localization and the formation of alternate
signaling complexes can alter the fate of cells stimulated through TNFRs with a death
domain, also known as" death receptors."
ranging from inflammation to apoptosis and other forms of programmed cell death. How
receptor signaling mediates these divergent responses is just beginning to be understood.
Here, we discuss how receptor submembrane localization and the formation of alternate
signaling complexes can alter the fate of cells stimulated through TNFRs with a death
domain, also known as" death receptors."
Abstract
Signaling by receptors in the TNF receptor (TNFR) superfamily mediate biological outcomes ranging from inflammation to apoptosis and other forms of programmed cell death. How receptor signaling mediates these divergent responses is just beginning to be understood. Here, we discuss how receptor submembrane localization and the formation of alternate signaling complexes can alter the fate of cells stimulated through TNFRs with a death domain, also known as "death receptors."
cell.com