Dendritic cells are decreased in blood and accumulated in granuloma in tuberculosis
K Uehira, R Amakawa, T Ito, K Tajima, S Naitoh… - Clinical …, 2002 - Elsevier
Immunity against tuberculosis consists of innate and adaptive immune responses. In this
study, we investigated the dynamics of dendritic cells (DC), which are known to elicit a
variety of immune responses, in patients with tuberculosis. CD11c+ peripheral blood DC
were decreased in patients with tuberculosis. Immunohistochemical analyses demonstrated
that a number of fascin+, CD11c+, HLA-DR+ DC were infiltrating the lymphocyte areas of the
tuberculous granulomas (tubercles). Immunohistochemical analyses also demonstrated that …
study, we investigated the dynamics of dendritic cells (DC), which are known to elicit a
variety of immune responses, in patients with tuberculosis. CD11c+ peripheral blood DC
were decreased in patients with tuberculosis. Immunohistochemical analyses demonstrated
that a number of fascin+, CD11c+, HLA-DR+ DC were infiltrating the lymphocyte areas of the
tuberculous granulomas (tubercles). Immunohistochemical analyses also demonstrated that …