[HTML][HTML] Effect of CD3δ deficiency on maturation of α/β and γ/δ T-cell lineages in severe combined immunodeficiency
HK Dadi, AJ Simon, CM Roifman - New England Journal of …, 2003 - Mass Medical Soc
HK Dadi, AJ Simon, CM Roifman
New England Journal of Medicine, 2003•Mass Medical SocThree closely related infants with a form of severe combined immunodeficiency
characterized by the absence of T cells but normal numbers of B cells were found to have an
identical germ-line mutation in the CD3δ gene. The mutation prevented synthesis of the
CD3δ protein and was associated with a block early in the development of thymocytes into
mature T cells.
characterized by the absence of T cells but normal numbers of B cells were found to have an
identical germ-line mutation in the CD3δ gene. The mutation prevented synthesis of the
CD3δ protein and was associated with a block early in the development of thymocytes into
mature T cells.
Three closely related infants with a form of severe combined immunodeficiency characterized by the absence of T cells but normal numbers of B cells were found to have an identical germ-line mutation in the CD3δ gene. The mutation prevented synthesis of the CD3δ protein and was associated with a block early in the development of thymocytes into mature T cells.
The New England Journal Of Medicine