Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A–TCRAD juxtaposition
S Bug, J Dürig, F Oyen, L Klein-Hitpass… - Cancer genetics and …, 2009 - Elsevier
In T-cell prolymphocytic leukemia (T-PLL), chromosomal imbalances affecting the long arm
of chromosome 22 are regarded as typical chromosomal aberrations secondary to a TCRAD–
TCL1A fusion due to inv (14) or t (14; 14). We analyzed recently obtained data from
conventional karyotyping, SNP-chip array copy number mapping, genome-wide expression
profiling, and interphase fluorescence in situ hybridization (FISH) of inv (14)-positive T-PLL
with respect to structural aberrations on chromosome 22. Combined gene chip and …
of chromosome 22 are regarded as typical chromosomal aberrations secondary to a TCRAD–
TCL1A fusion due to inv (14) or t (14; 14). We analyzed recently obtained data from
conventional karyotyping, SNP-chip array copy number mapping, genome-wide expression
profiling, and interphase fluorescence in situ hybridization (FISH) of inv (14)-positive T-PLL
with respect to structural aberrations on chromosome 22. Combined gene chip and …