BRCA1 and stem cells: tumour typecasting
MJ Smalley, JS Reis-Filho, A Ashworth - nature cell biology, 2008 - nature.com
MJ Smalley, JS Reis-Filho, A Ashworth
nature cell biology, 2008•nature.comPhenotypic variation between tumour types is likely to reflect the nature of the cell of origin
and the genes involved in pathogenesis. Compared with most sporadic breast cancers,
those arising in carriers of BRCA1 mutations usually have distinctive pathological
characteristics. A new study suggests that a role for BRCA1 in the determination of stem-cell
fate may explain this phenomenon.
and the genes involved in pathogenesis. Compared with most sporadic breast cancers,
those arising in carriers of BRCA1 mutations usually have distinctive pathological
characteristics. A new study suggests that a role for BRCA1 in the determination of stem-cell
fate may explain this phenomenon.
Phenotypic variation between tumour types is likely to reflect the nature of the cell of origin and the genes involved in pathogenesis. Compared with most sporadic breast cancers, those arising in carriers of BRCA1 mutations usually have distinctive pathological characteristics. A new study suggests that a role for BRCA1 in the determination of stem-cell fate may explain this phenomenon.
nature.com