Tumors: wounds that do not heal
HF Dvorak - New England Journal of Medicine, 1986 - Mass Medical Soc
HF Dvorak
New England Journal of Medicine, 1986•Mass Medical SocSOLID tumors are composed of two discrete but interdependent compartments: the
malignant cells themselves and the stroma that they induce and in which they are dispersed.
1, 2 In tumors of epithelialcell origin—carcinomas—a basement membrane is often
interposed between the tumor cells and the stroma, but in other types of tumors, malignant
cells directly abut on or intermingle with stromal elements. 1, 3 An appreciation of tumor
stroma is essential to an understanding of the biology of tumor growth; all solid tumors …
malignant cells themselves and the stroma that they induce and in which they are dispersed.
1, 2 In tumors of epithelialcell origin—carcinomas—a basement membrane is often
interposed between the tumor cells and the stroma, but in other types of tumors, malignant
cells directly abut on or intermingle with stromal elements. 1, 3 An appreciation of tumor
stroma is essential to an understanding of the biology of tumor growth; all solid tumors …
SOLID tumors are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.1 , 2 In tumors of epithelialcell origin — carcinomas — a basement membrane is often interposed between the tumor cells and the stroma, but in other types of tumors, malignant cells directly abut on or intermingle with stromal elements.1 , 3
An appreciation of tumor stroma is essential to an understanding of the biology of tumor growth; all solid tumors, regardless of their site of origin, require stroma if they are to grow beyond a minimal size of . . .
The New England Journal Of Medicine