Aspirin and cancer risk: a summary review to 2007

C Bosetti, S Gallus, CL Vecchia - Cancer Prevention II, 2009 - Springer
Cancer Prevention II, 2009Springer
With few exceptions, epidemiological studies have found that individuals who take
nonsteroidal antiinflammatory drugs (NSAIDs) have a reduced risk of colorectal adenomas
and carcinoma. Similarly, randomized studies in patients with familial adenomatous
polyposis have uniformly found that NSAIDs can lead to polyp regression and prevention of
new polyps, and trials in patients with sporadic adenomas document that aspirin reduces the
risk of adenoma recurrence. Together these data provide convincing evidence for the …
Abstract
With few exceptions, epidemiological studies have found that individuals who take nonsteroidal antiinflammatory drugs (NSAIDs) have a reduced risk of colorectal adenomas and carcinoma. Similarly, randomized studies in patients with familial adenomatous polyposis have uniformly found that NSAIDs can lead to polyp regression and prevention of new polyps, and trials in patients with sporadic adenomas document that aspirin reduces the risk of adenoma recurrence. Together these data provide convincing evidence for the chemopreventive efficacy of NSAIDs in the large bowel.
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