Spleen is a common site of extramedullary hematopoiesis. Extramedullary hematopoiesis
seen in non-neoplastic conditions can occasionally be extensive and raise concerns for a
myeloid neoplasm. We compared the morphologic and immunohistochemical features of
splenic hematopoietic proliferations seen in neoplastic myeloid disorders (eg chronic
myeloproliferative disorders, myelodysplastic/myeloproliferative disorders and acute
myeloid leukemias) to extramedullary hematopoiesis seen in a variety of reactive conditions …