VIP-secreting tumours are rare, but they produce a dramatic clinical picture, the most
prominent feature being profuse, watery diarrhoea and hypokalaemia. VIPomas are
malignant and require sophisticated diagnostic and localization techniques in order to
identify their presence. Delays in diagnosis are the rule rather than the exception.
Improvements in the diagnosis of VIPomas appear to result in an increase in resectability
rates. A definitive diagnosis is aided by the determination of plasma VIP concentrations …