[HTML][HTML] Molecular cloning of the helodermin and exendin-4 cDNAs in the lizard: Relationship to vasoactive intestinal polypeptide/pituitary adenylate cyclase activating …
M Pohl, SA Wank - Journal of Biological Chemistry, 1998 - ASBMB
Helodermin and exendin-4, two peptides isolated from the salivary gland of the Gila
monster, Heloderma suspectum, are approximately 50% homologous to vasoactive
intestinal peptide (VIP) and glucagon-like peptide-1 (GLP-1), respectively, and interact with
the mammalian receptors for VIP and GLP-1 with equal or higher affinity and efficacy.
Immunohistochemical studies suggested the presence of helodermin-like peptides in
mammals. To determine whether helodermin and exendin-4 are present in mammals and …
monster, Heloderma suspectum, are approximately 50% homologous to vasoactive
intestinal peptide (VIP) and glucagon-like peptide-1 (GLP-1), respectively, and interact with
the mammalian receptors for VIP and GLP-1 with equal or higher affinity and efficacy.
Immunohistochemical studies suggested the presence of helodermin-like peptides in
mammals. To determine whether helodermin and exendin-4 are present in mammals and …