[HTML][HTML] Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and α3 integrin
Podocyte foot process effacement and disruption of the slit diaphragm are typically
associated with glomerular proteinuria and can be induced in rats by the injection of
puromycin aminonucleoside. Here, we show that the induction of puromycin
aminonucleoside nephrosis involves podocyte migration conducted by a coordinated
interplay between the cysteine protease cathepsin L and α 3 integrin. Puromycin
aminonucleoside treatment up-regulates cathepsin L expression in podocytes in vivo as well …
associated with glomerular proteinuria and can be induced in rats by the injection of
puromycin aminonucleoside. Here, we show that the induction of puromycin
aminonucleoside nephrosis involves podocyte migration conducted by a coordinated
interplay between the cysteine protease cathepsin L and α 3 integrin. Puromycin
aminonucleoside treatment up-regulates cathepsin L expression in podocytes in vivo as well …