Recent reports have indicated that components of the complement cascade are synthesized
during the degeneration of retinal ganglion cells (RGC) in glaucoma. While complement
deposition in the retina may simply serve to aid phagocytosis of damaged RGC, activation of
the complement cascade can also contribute to neuronal loss in neurodegenerative
diseases. This study was designed to determine if disruption of the complement cascade
affects RGC survival in a murine model of retinal ischemia-reperfusion (I/R) injury. We …