[HTML][HTML] Glial cell line-derived neurotrophic factor regulation of genes essential for self-renewal of mouse spermatogonial stem cells is dependent on Src family kinase …
JM Oatley, MR Avarbock, RL Brinster - Journal of Biological Chemistry, 2007 - ASBMB
Self-renewal and differentiation by spermatogonial stem cells (SSCs) is the foundation for
continual spermatogenesis. SSC self-renewal is dependent on glial cell line-derived
neurotrophic factor (GDNF); however, intracellular mechanisms stimulated by GDNF in
SSCs are unknown. To investigate these mechanisms we utilized a culture system that
maintains a mouse undifferentiated germ cell population enriched for self-renewing SSCs. In
these cultures mRNA for the transcription factors Bcl6b, Erm, and Lhx1 are up-regulated by …
continual spermatogenesis. SSC self-renewal is dependent on glial cell line-derived
neurotrophic factor (GDNF); however, intracellular mechanisms stimulated by GDNF in
SSCs are unknown. To investigate these mechanisms we utilized a culture system that
maintains a mouse undifferentiated germ cell population enriched for self-renewing SSCs. In
these cultures mRNA for the transcription factors Bcl6b, Erm, and Lhx1 are up-regulated by …