Virus interference. I. The interferon
A Isaacs, J Lindenmann - … of the Royal Society of London …, 1957 - royalsocietypublishing.org
A Isaacs, J Lindenmann
Proceedings of the Royal Society of London. Series B …, 1957•royalsocietypublishing.orgDuring a study of the interference produced by heat-inactivated influenza virus with the
growth of live virus in fragments of chick chorio-allantoic membrane it was found that
following incubation of heated virus with membrane a new factor was released. This factor,
recognized by its ability to induce interference in fresh pieces of chorio-allantoic membrane,
was called interferon. Following a lag phase interferon was first detected in the membranes
after 3 h incubation and thereafter it was released into the surrounding fluid.
growth of live virus in fragments of chick chorio-allantoic membrane it was found that
following incubation of heated virus with membrane a new factor was released. This factor,
recognized by its ability to induce interference in fresh pieces of chorio-allantoic membrane,
was called interferon. Following a lag phase interferon was first detected in the membranes
after 3 h incubation and thereafter it was released into the surrounding fluid.
During a study of the interference produced by heat-inactivated influenza virus with the growth of live virus in fragments of chick chorio-allantoic membrane it was found that following incubation of heated virus with membrane a new factor was released. This factor, recognized by its ability to induce interference in fresh pieces of chorio-allantoic membrane, was called interferon. Following a lag phase interferon was first detected in the membranes after 3 h incubation and thereafter it was released into the surrounding fluid.
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