The puzzle of intestinal lamina propria dendritic cells and macrophages
O Pabst, G Bernhardt - European journal of immunology, 2010 - Wiley Online Library
O Pabst, G Bernhardt
European journal of immunology, 2010•Wiley Online LibraryA specialized network of immune cells is positioned directly in the mucosa of the intestinal
tract. In this Viewpoint, we discuss the nature and function of DC and macrophages
occupying the intestinal lamina propria of mice. DC and macrophages share phenotypic
traits and functional plasticity, properties that preclude simple classification of the two cell
types. Nevertheless, the information available appears to have reached “critical mass” to
allow for a clear demarcation between intestinal macrophages and DC.
tract. In this Viewpoint, we discuss the nature and function of DC and macrophages
occupying the intestinal lamina propria of mice. DC and macrophages share phenotypic
traits and functional plasticity, properties that preclude simple classification of the two cell
types. Nevertheless, the information available appears to have reached “critical mass” to
allow for a clear demarcation between intestinal macrophages and DC.
Abstract
A specialized network of immune cells is positioned directly in the mucosa of the intestinal tract. In this Viewpoint, we discuss the nature and function of DC and macrophages occupying the intestinal lamina propria of mice. DC and macrophages share phenotypic traits and functional plasticity, properties that preclude simple classification of the two cell types. Nevertheless, the information available appears to have reached “critical mass” to allow for a clear demarcation between intestinal macrophages and DC.
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