[HTML][HTML] Two naturally occurring variants of TAFI (Thr-325 and Ile-325) differ substantially with respect to thermal stability and antifibrinolytic activity of the enzyme
Thrombin-activable fibrinolysis inhibitor (TAFI) is a carboxypeptidase B-like zymogen that is
activated to TAFIa by plasmin, thrombin, or the thrombin-thrombomodulin complex. The
enzyme TAFIa attenuates clot lysis by removing lysine residues from a fibrin clot. Screening
of nine human cDNA libraries indicated a common variation in TAFI at position 325 (Ile-325
or Thr-325). This is in addition to the variation at amino acid position 147 (Ala-147 or Thr-
147) characterized previously. Thus, four variants of TAFI having either Ala or Thr at position …
activated to TAFIa by plasmin, thrombin, or the thrombin-thrombomodulin complex. The
enzyme TAFIa attenuates clot lysis by removing lysine residues from a fibrin clot. Screening
of nine human cDNA libraries indicated a common variation in TAFI at position 325 (Ile-325
or Thr-325). This is in addition to the variation at amino acid position 147 (Ala-147 or Thr-
147) characterized previously. Thus, four variants of TAFI having either Ala or Thr at position …