Hyperglycemia is an independent risk factor for diabetic heart failure. However, the
mechanisms that mediate hyperglycemia-induced cardiac damage remain poorly
understood. The transcription factor GATA4 is essential for cardiac homeostasis, and its
protein levels are dramatically reduced in the heart in response to diverse pathologic
stresses. In this study, we investigated if hyperglycemia affects GATA4 expression in
cardiomyocytes and if enhancing GATA4 signaling could attenuate hyperglycemia-induced …