Chemistry-to-gene screens in Caenorhabditis elegans
AK Jones, SD Buckingham, DB Sattelle - Nature Reviews Drug …, 2005 - nature.com
AK Jones, SD Buckingham, DB Sattelle
Nature Reviews Drug Discovery, 2005•nature.comThe nematode worm Caenorhabditis elegans is a genetic model organism linked to an
impressive portfolio of fundamental discoveries in biology. This free-living nematode, which
can be easily and inexpensively grown in the laboratory, is also a natural vehicle for
screening for drugs that are active against nematode parasites. Here, we show that
chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs,
identify novel candidate drug targets and contribute to the discovery of new drugs for treating …
impressive portfolio of fundamental discoveries in biology. This free-living nematode, which
can be easily and inexpensively grown in the laboratory, is also a natural vehicle for
screening for drugs that are active against nematode parasites. Here, we show that
chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs,
identify novel candidate drug targets and contribute to the discovery of new drugs for treating …
Abstract
The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases.
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