A circulatory model for calculating non-steady-state glucose fluxes. Validation and comparison with compartmental models

A Mari, L Stojanovska, J Proietto… - Computer methods and …, 2003 - Elsevier
Computer methods and programs in biomedicine, 2003Elsevier
This study presents a circulatory model of glucose kinetics for application to non-steady-
state conditions, examines its ability to predict glucose appearance rates from a simulated
oral glucose load, and compares its performance with compartmental models. A glucose
tracer bolus was injected intravenously in rats to determine parameters of the circulatory and
two-compartment models. A simulated oral glucose tolerance test was performed in another
group of rats by infusing intravenously labeled glucose at variable rates. A primed …
This study presents a circulatory model of glucose kinetics for application to non-steady-state conditions, examines its ability to predict glucose appearance rates from a simulated oral glucose load, and compares its performance with compartmental models. A glucose tracer bolus was injected intravenously in rats to determine parameters of the circulatory and two-compartment models. A simulated oral glucose tolerance test was performed in another group of rats by infusing intravenously labeled glucose at variable rates. A primed continuous intravenous infusion of a second tracer was given to determine glucose clearance. The circulatory model gave the best estimate of glucose appearance, closely followed by the two-compartment model and a modified Steele one-compartment model with a larger total glucose volume. The standard one-compartment model provided the worst estimate. The average relative errors on the rate of glucose appearance were: circulatory, 10%; two-compartment, 13%; modified one-compartment, 11%; standard one-compartment, 16%. Recovery of the infused glucose dose was 93±2, 94±2, 92±2 and 85±2%, respectively. These results show that the circulatory model is an appropriate model for assessing glucose turnover during an oral glucose load.
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