Insulin action on the liver in vivo
AD Cherrington, MC Moore, DK Sindelar… - Biochemical Society …, 2007 - portlandpress.com
AD Cherrington, MC Moore, DK Sindelar, DS Edgerton
Biochemical Society Transactions, 2007•portlandpress.comInsulin has a potent inhibitory effect on hepatic glucose production by direct action at hepatic
receptors. The hormone also inhibits glucose production by suppressing both lipolysis in the
fat cell and secretion of glucagon by the α-cell. Neural sensing of insulin levels appears to
participate in control of hepatic glucose production in rodents, but a role for brain insulin
sensing has not been documented in dogs or humans. The primary effect of insulin on the
liver is its direct action.
receptors. The hormone also inhibits glucose production by suppressing both lipolysis in the
fat cell and secretion of glucagon by the α-cell. Neural sensing of insulin levels appears to
participate in control of hepatic glucose production in rodents, but a role for brain insulin
sensing has not been documented in dogs or humans. The primary effect of insulin on the
liver is its direct action.
Insulin has a potent inhibitory effect on hepatic glucose production by direct action at hepatic receptors. The hormone also inhibits glucose production by suppressing both lipolysis in the fat cell and secretion of glucagon by the α-cell. Neural sensing of insulin levels appears to participate in control of hepatic glucose production in rodents, but a role for brain insulin sensing has not been documented in dogs or humans. The primary effect of insulin on the liver is its direct action.
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