Over 40 years ago, Mabel and Lowell Hokin published their seminal work demonstrating
that phosphoinositides (PI) are rapidly metabolized by cells in response to stimuli, thereby
founding the field of inositol signaling (1). In more recent years the tremendous complexity of
the inositol metabolic pathway has become evident (2–7). Diverse stimuli such as growth
factors, hormones, neurotransmitters, cell differentiation and developmental signals,
cytokines and light activate molecular programs that lead to the production of numerous …