[HTML][HTML] Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium: evidence for autoregulation of GSK-3
F Zhang, CJ Phiel, L Spece, N Gurvich… - Journal of Biological …, 2003 - ASBMB
Glycogen synthase kinase-3 (GSK-3) is a critical, negative regulator of diverse signaling
pathways. Lithium is a direct inhibitor of GSK-3 and has been widely used to test the putative
role of GSK-3 in multiple settings. However, lithium also inhibits other targets, including
inositol monophosphatase and structurally related phosphomonoesterases, and thus
additional approaches are needed to attribute a given biological effect of lithium to a specific
target. For example, lithium is known to increase the inhibitory N-terminal phosphorylation of …
pathways. Lithium is a direct inhibitor of GSK-3 and has been widely used to test the putative
role of GSK-3 in multiple settings. However, lithium also inhibits other targets, including
inositol monophosphatase and structurally related phosphomonoesterases, and thus
additional approaches are needed to attribute a given biological effect of lithium to a specific
target. For example, lithium is known to increase the inhibitory N-terminal phosphorylation of …