[HTML][HTML] Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3
Lithium is one of the most widely used drugs for treating bipolar (manic-depressive)
disorder. Despite its efficacy, the molecular mechanism underlying its action has not been
elucidated. One recent study has proposed that lithium inhibits glycogen synthase kinase-3
and thereby affects multiple cellular functions. Because glycogen synthase kinase-3
regulates the phosphorylation of tau (microtubule-binding protein that forms paired helical
filaments in neurons of the Alzheimer's disease brain), we hypothesized that lithium could …
disorder. Despite its efficacy, the molecular mechanism underlying its action has not been
elucidated. One recent study has proposed that lithium inhibits glycogen synthase kinase-3
and thereby affects multiple cellular functions. Because glycogen synthase kinase-3
regulates the phosphorylation of tau (microtubule-binding protein that forms paired helical
filaments in neurons of the Alzheimer's disease brain), we hypothesized that lithium could …