Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model
T Barkhausen, T Tschernig, P Rosenstiel… - Critical care …, 2011 - journals.lww.com
Objective: The pleiotropic cytokine interleukin (IL)-6 seems to play a pivotal role in sepsis,
but contradictory findings in animal models impede a rationale for therapies directed against
IL-6. IL-6 signals by two mechanisms via the ubiquitous transmembrane glycoprotein 130
(gp130):“classic” signaling using membrane-bound IL-6 receptor (IL-6R) and trans-signaling
using soluble IL-6R (sIL-6R). Trans-signaling is selectively inhibited by soluble gp130
(sgp130). The aim of this study was to systematically compare complete blockade of IL-6 …
but contradictory findings in animal models impede a rationale for therapies directed against
IL-6. IL-6 signals by two mechanisms via the ubiquitous transmembrane glycoprotein 130
(gp130):“classic” signaling using membrane-bound IL-6 receptor (IL-6R) and trans-signaling
using soluble IL-6R (sIL-6R). Trans-signaling is selectively inhibited by soluble gp130
(sgp130). The aim of this study was to systematically compare complete blockade of IL-6 …