[HTML][HTML] Activation of the Jak2-Stat5 signaling pathway in Nb2 lymphoma cells by an anti-apoptotic agent, aurintricarboxylic acid
Biological effects of many hormones and cytokines are mediated through receptor-
associated Jak tyrosine kinases and cytoplasmic Stat transcription factors, including critical
physiological processes such as immunity, reproduction, and cell growth and differentiation.
Pharmaceuticals that control Jak-Stat pathways are therefore of considerable interest. Here
we demonstrate that a single Jak-Stat pathway can be activated by aurintricarboxylic acid
(ATA), a negatively charged triphenylmethane derivative (475 Da) with anti-apoptotic …
associated Jak tyrosine kinases and cytoplasmic Stat transcription factors, including critical
physiological processes such as immunity, reproduction, and cell growth and differentiation.
Pharmaceuticals that control Jak-Stat pathways are therefore of considerable interest. Here
we demonstrate that a single Jak-Stat pathway can be activated by aurintricarboxylic acid
(ATA), a negatively charged triphenylmethane derivative (475 Da) with anti-apoptotic …