Neuronal effects of acute citalopram detected by pharmacoMRI
Psychopharmacology, 2005•Springer
Abstract Rationale Serotonin (5-hydroxytryptamine, 5-HT) is implicated in the aetiology and
treatment of a variety of psychiatric disorders. A limitation of research has been the necessity
to use indirect measures of 5-HT function. Method We describe a method of analysing
pharmacoMRI data using SPM and apply it to the direct iv infusion of selective 5-HT
reuptake inhibitor, citalopram, in 12 healthy volunteers. Scanning took place on a 1.5-T
Philips MRI scanner. Results Areas implicated in depression and its treatment were …
treatment of a variety of psychiatric disorders. A limitation of research has been the necessity
to use indirect measures of 5-HT function. Method We describe a method of analysing
pharmacoMRI data using SPM and apply it to the direct iv infusion of selective 5-HT
reuptake inhibitor, citalopram, in 12 healthy volunteers. Scanning took place on a 1.5-T
Philips MRI scanner. Results Areas implicated in depression and its treatment were …
Rationale
Serotonin (5-hydroxytryptamine, 5-HT) is implicated in the aetiology and treatment of a variety of psychiatric disorders. A limitation of research has been the necessity to use indirect measures of 5-HT function.
Method
We describe a method of analysing pharmacoMRI data using SPM and apply it to the direct i.v. infusion of selective 5-HT reuptake inhibitor, citalopram, in 12 healthy volunteers. Scanning took place on a 1.5-T Philips MRI scanner.
Results
Areas implicated in depression and its treatment were observed to have increasing signal with respect to time. These areas included the caudate, the amygdala, the hippocampus, the striatum and the thalamus.
Conclusion
Direct pMRI using i.v. citalopram opens new ways of investigating 5-HT mechanism in depression and its treatment.
Springer