Purpose: Sodium valproate is a commonly used anticonvulsant in the management of
childhood refractory epilepsy with good response rates and acceptable toxicity.
Hepatotoxicity is the most widely recognized toxicity. With the use of higher drug levels to
achieve adequate seizure control, hematologic toxicity is being increasingly encountered,
and the pediatric hematologist is consulted for these problems in the pre-or perioperative
setting. The purpose of this article is to characterize the various hematologic toxicities …