Procarboxypeptidase U (TAFI) contributes to the risk of thrombosis in patients with hereditary thrombophilia
E Heylen, P Miljic, J Willemse, V Djordjevic… - Thrombosis research, 2009 - Elsevier
INTRODUCTION: It is considered that high plasma levels of procarboxypeptidase U
(proCPU or TAFI) can promote the development of thrombosis, but data comparing proCPU
levels in thrombophilia carriers and healthy subjects are rather scarce. Moreover, the results
of previous studies on the risk of thrombosis related to high proCPU concentration in this
population were not consistent. Although the 325 polymorphism of proCPU has a significant
effect on the CPU half-life, it's influence on the risk of thrombosis or spontaneous pregnancy …
(proCPU or TAFI) can promote the development of thrombosis, but data comparing proCPU
levels in thrombophilia carriers and healthy subjects are rather scarce. Moreover, the results
of previous studies on the risk of thrombosis related to high proCPU concentration in this
population were not consistent. Although the 325 polymorphism of proCPU has a significant
effect on the CPU half-life, it's influence on the risk of thrombosis or spontaneous pregnancy …