Procarboxypeptidase R deficiency causes increased lethality in concanavalin A-induced hepatitis in female mice
S Asai, N Kimbara, T Tada, M Imai… - Biological and …, 2010 - jstage.jst.go.jp
S Asai, N Kimbara, T Tada, M Imai, W Campbell, H Okada, N Okada
Biological and Pharmaceutical Bulletin, 2010•jstage.jst.go.jpMATERIALS AND METHODS Animals As described previously, proCPR/ mice (129/Ola,
BALB/c, and C57BL/6 background) were generated by knocking out the portion of the gene
containing exons 4 and 5 to eliminate all CPR activity. 11) In this study, we used 5-to 8-week-
old proCPR/mice. Similar background proCPR/mice were used as controls. It has been
confirmed that there was no gender difference in CPN and CPR activities in these
proCPR/and proCPR/mice. The experimental protocol was approved by the Animal Studies …
BALB/c, and C57BL/6 background) were generated by knocking out the portion of the gene
containing exons 4 and 5 to eliminate all CPR activity. 11) In this study, we used 5-to 8-week-
old proCPR/mice. Similar background proCPR/mice were used as controls. It has been
confirmed that there was no gender difference in CPN and CPR activities in these
proCPR/and proCPR/mice. The experimental protocol was approved by the Animal Studies …
MATERIALS AND METHODS
Animals As described previously, proCPR/ mice (129/Ola, BALB/c, and C57BL/6 background) were generated by knocking out the portion of the gene containing exons 4 and 5 to eliminate all CPR activity. 11) In this study, we used 5-to 8-week-old proCPR/mice. Similar background proCPR/mice were used as controls. It has been confirmed that there was no gender difference in CPN and CPR activities in these proCPR/and proCPR/mice. The experimental protocol was approved by the Animal Studies Committee of Nagoya City University Graduate School of Medical Sciences.
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