Bone marrow derived mesenchymal stem cells from chronic myeloid leukemia t (9; 22) patients are devoid of Philadelphia chromosome and support cord blood stem …
S Jootar, N Pornprasertsud, S Petvises… - Leukemia research, 2006 - Elsevier
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of hematopoietic
stem cells. It is characterized at cytogenetic level by the Philadelphia (Ph) chromosome and
at the molecular level by the BCR/ABL gene rearrangement. Bone marrow derived
mesenchymal stem cells (MSCs) are also pluripotent stem cells that can differentiate into
several mesenchymal tissues. To date, no study has been performed to characterize
whether MSCs from CML harbor the abnormal Ph chromosome similar to CML bone marrow …
stem cells. It is characterized at cytogenetic level by the Philadelphia (Ph) chromosome and
at the molecular level by the BCR/ABL gene rearrangement. Bone marrow derived
mesenchymal stem cells (MSCs) are also pluripotent stem cells that can differentiate into
several mesenchymal tissues. To date, no study has been performed to characterize
whether MSCs from CML harbor the abnormal Ph chromosome similar to CML bone marrow …