Cardiac sympathetic denervation preceding motor signs in Parkinson disease
DS Goldstein, Y Sharabi, BI Karp, O Bentho… - Clinical Autonomic …, 2007 - Springer
Clinical Autonomic Research, 2007•Springer
There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD).
Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in
de novo PD, but whether these abnormalities can precede PD has been unknown. Here we
report the case of a patient who had profoundly decreased left ventricular myocardial 6-[18
F] fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4 years before
the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac …
Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in
de novo PD, but whether these abnormalities can precede PD has been unknown. Here we
report the case of a patient who had profoundly decreased left ventricular myocardial 6-[18
F] fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4 years before
the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac …
Abstract
There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has been unknown. Here we report the case of a patient who had profoundly decreased left ventricular myocardial 6-[18F]fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4 years before the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD.
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