Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells
Molecular biology of the cell, 2009•Am Soc Cell Biol
A major regulatory function has been evidenced here for HSF1, the key transcription factor of
the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon
heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-
wide and massive histone deacetylation. Investigating the underlying mechanisms, we show
that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-
shock–dependent histone deacetylation. This work therefore identifies HSF1 as a master …
the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon
heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-
wide and massive histone deacetylation. Investigating the underlying mechanisms, we show
that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-
shock–dependent histone deacetylation. This work therefore identifies HSF1 as a master …
A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation. Investigating the underlying mechanisms, we show that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock–dependent histone deacetylation. This work therefore identifies HSF1 as a master regulator of global chromatin acetylation and reveals a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock.
Am Soc Cell Biol