Cornel iridoid glycoside promotes neurogenesis and angiogenesis and improves neurological function after focal cerebral ischemia in rats
RQ Yao, L Zhang, W Wang, L Li - Brain Research Bulletin, 2009 - Elsevier
The aim of this study was to investigate the effects of cornel iridoid glycoside (CIG), an
ingredient extracted from a traditional Chinese herb Cornus officinalis, on neurological
function and neurogenesis after ischemic stroke. CIG was intragastrically administered to
rats in doses of 20, 60 and 180mg/kg/day, starting 3h after the onset of middle cerebral
artery occlusion (MCAO). The behavioral test was performed by using the modified
neurological severity score (mNSS). Rats were sacrificed 7, 14, or 28 days after ischemia …
ingredient extracted from a traditional Chinese herb Cornus officinalis, on neurological
function and neurogenesis after ischemic stroke. CIG was intragastrically administered to
rats in doses of 20, 60 and 180mg/kg/day, starting 3h after the onset of middle cerebral
artery occlusion (MCAO). The behavioral test was performed by using the modified
neurological severity score (mNSS). Rats were sacrificed 7, 14, or 28 days after ischemia …