The Levine rat prepartion, the gerbil stroke model, and appropriate control animals were
used to determine if the 2, 3, 5-triphenyltetrazolium chloride (TTC) would selectively identify
noninfarcted versus infarcted cerebral tissue. The TTC is frequently used to quantify
infarcted myocardial tissue and has been shown to have great specificity, reproducibility,
and efficacy. The TTC produces a red product upon reaction with the respiratory enzymes
(dehydrogenases) present in non-infarcted tissues. Irreversibly damaged tissues, lacking …