[HTML][HTML] Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan
M Mongiat, SM Sweeney, JD San Antonio, J Fu… - Journal of Biological …, 2003 - ASBMB
Perlecan, a ubiquitous basement membrane heparan sulfate proteoglycan, plays key roles
in blood vessel growth and structural integrity. We discovered that the C terminus of
perlecan potently inhibited four aspects of angiogenesis: endothelial cell migration, collagen-
induced endothelial tube morphogenesis, and blood vessel growth in the chorioallantoic
membrane and in Matrigel plug assays. The C terminus of perlecan was active at nanomolar
concentrations and blocked endothelial cell adhesion to fibronectin and type I collagen …
in blood vessel growth and structural integrity. We discovered that the C terminus of
perlecan potently inhibited four aspects of angiogenesis: endothelial cell migration, collagen-
induced endothelial tube morphogenesis, and blood vessel growth in the chorioallantoic
membrane and in Matrigel plug assays. The C terminus of perlecan was active at nanomolar
concentrations and blocked endothelial cell adhesion to fibronectin and type I collagen …