Correlation of muscle fiber type measurements with clinical and molecular genetic data in Duchenne muscular dystrophy

JF Wang, J Forst, S Schröder, JM Schröder - Neuromuscular Disorders, 1999 - Elsevier
Clinical improvement following surgery in patients with Duchenne muscular dystrophy
(DMD) may be influenced by the severity of muscle fiber damage. This study correlates
morphometric alterations of muscle fiber types, severity of fat tissue proliferation and fibrosis
with Western blots, multiplex polymerase chain reaction (PCR), and postoperative state in
DMD. The main results of this study show that the mean diameter of type 2 fibers is usually
markedly larger than that of type 1 fibers in DMD although the number of type 2 fibers is …